Principal investigator: F. Anagnostou
A dental implant aims at replacing a missing or damaged tooth with an artificial root inserted into the alveolar bone (bone portion holding the tooth in place) to restore the aesthetics and chewing function.
The success of the surgical procedure relies mostly on a good osseo-integration of the implant that depends of different conditions such as:
- A good mechanical stability to minimize the micro-movements;
- The prevention of infection;
- The colonization of the peri-implantation blood clot by osteoprogenitor cells.
Moreover, the absence of alveolar bone caused by periodontal diseases, birth defects… constitutes a major clinical problem for the implant placement.
The physico-chemical properties, as well as the surface topography, of the implant can influence the quantity, but also the quality, of the newly formed bone on the implant surface. These properties can, therefore, be used to modulate and improve the implant osseointegration. The B3OA developped pre-clinical models :
- To test the quality of the implant osseointegration;
- To characterize the molecular mechanisms taking place at the implant/bone interface in order to evaluate the reaction of the surrounding bone.
Publications of the project
Chakar C, Soffer E, Cohen N, Petite H, Naaman N, Anagnostou F. Vertical bone regeneration with deproteinised bovine bone mineral or biphasic calcium phosphate in the rabbit calvarium: effect of autologous platelet lysate. J Mater Sci Mater Med. 2015 Jan;26(1):5339. Link for the publication .