A New Microarchitecture-Based Parameter to Predict the Micromechanical Properties of Bone Allografts
This study presents a novel microarchitectural parameter that could be used to predict the level of mechanical stimulation at the cellular level, a key parameter to better understand and optimize the mechanism of osteogenesis in bone tissue engineering.
Three-dimensional Printing of Biomimetic Titanium Mimicking Trabecular Bone Induces Human Mesenchymal Stem Cell Proliferation: An In-vitro Analysis
The aim of this study was to assess the effect of three-dimensional (3D) printing of porous titanium on human mesenchymal stem cell (hMSC) adhesion, proliferation, and osteogenic differentiation.
Glucose Metabolism: Optimizing Regenerative Functionalities of Mesenchymal Stromal Cells Postimplantation
Following a brief overview of glucose metabolism and regulation in MSCs, the present literature review includes recent pertinent findings that challenge old paradigms and notions
This review aimed to provide an update to a broader concept of stem cell fate in stress conditions of damaged tissues, and insights for the mitochondrial hormesis (mitohormesis), including the integrated stress response (ISR), mitochondrial dynamics, mitochondria uncoupling, unfolded protein response, and mitokines, with implications for the control of stem cells programing in a successful clinical cell therapy
In Vivo bone tissue induction by freeze-dried collagen-nanohydroxyapatite matrix loaded with BMP2/NS1 mRNAs lipopolyplexes
Overall, our results demonstrate that the BMP2/NS1 dual mRNAs system is suitable for osteogenic engagement, and the freeze-dried RAM-BMP2/NS1 could be promising off-the-shelf products for clinical orthopedic practice
Virtual monoenergetic images from photon-counting spectral computed tomography to assess knee osteoarthritis
Virtual monoenergetic images may provide direct visualisation of both cartilage and bone details. Thus, unenhanced PCSCT appears to be a new modality for characterising the knee joint with the potential to increase the diagnostic capability of computed tomography for joint diseases and osteoarthritis.
Experimental Type 2 Diabetes Differently Impacts on the Select Functions of Bone Marrow-Derived Multipotent Stromal Cells
These results provided evidence that the type 2 diabetes environment impairs multipotent stromal cell expansion and select functions pertinent to their efficacy when used in autologous cell therapies.
Human dentin characteristics of patients with osteogenesis imperfecta: insights into collagen-based biomaterials
We investigated the collagen, mineral and mechanical properties of dentin from deciduous teeth collected from patients with mild form of osteogenesis imperfecta and displaying no obvious clinical signs of dentinogenesis imperfecta. For the first time, an increase in the hardness of osteogenesis imperfecta dentin associated with an increase in mineral content compared to healthy patients was reported.
This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality.
Does eccentric-concentric resistance training improve early functional outcomes compared to concentric resistance training after total knee arthroplasty?
This study showed that early combined eccentric-concentric rehabilitation after total knee arthroplasty appears to be associated with improved outcomes compared to classic concentric rehabilitation protocols, on both physical function and quality of life.
Osteogenic-differentiated mesenchymal stem cell-secreted extracellular matrix as a bone morphogenetic protein-2 delivery system for ectopic bone formation
This study provided evidence that the osteoinductive potential of BMP-2 was greater when loaded within an osteogenic MSC-derived ECM.
In the present review, we aimed to identify the up-to-date biological effects and underlying mechanisms of astaxanthin on the ROS-induced diabetes mellitus-associated metabolic disorders and subsequent complications
Custom-made macroporous bioceramic implants based on triply-periodic minimal surfaces for bone defects in load-bearing sites
This study showed, for the first time, that custom-made TPMS-based bioceramic implants could be produced and successfully implanted in load-bearing sites
Concise review: Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications
Here, we provide a comprehensive review of plausible metabolic switches in response to implantation and of the various strategies currently used to leverage MSC metabolism to improve stem cell-based therapeutics.
Effect of the bone morphogenetic protein-2 doses on the osteogenic potential of human multipotent stromal cells-containing tissue engineered constructs
Our results showed that the addition of only low dose of BMP-2 was beneficial to enhance the bone-forming potential of MSCs, whereas high dose of BMP-2 overcame the advantage of combining this growth factor with MSCs.
In this uncontrolled study, airway bioengineering using stented aortic matrices demonstrated feasibility for complex tracheal and bronchial reconstruction.
Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats
The present study provided evidence that T2DM impairs bone formation in critical-size calvarial defects and markedly reduces angiogenesis in all defects regardless of the defect size tested.