Does physical exercise always improve bone quality in rats?

This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality.

Does eccentric-concentric resistance training improve early functional outcomes compared to concentric resistance training after total knee arthroplasty?

This study showed that early combined eccentric-concentric rehabilitation after total knee arthroplasty appears to be associated with improved outcomes compared to classic concentric rehabilitation protocols, on both physical function and quality of life.

Osteogenic-differentiated mesenchymal stem cell-secreted extracellular matrix as a bone morphogenetic protein-2 delivery system for ectopic bone formation

This study provided evidence that the osteoinductive potential of BMP-2 was greater when loaded within an osteogenic MSC-derived ECM.

Impact of astaxanthin on diabetes pathogenesis and chronic complications

In the present review, we aimed to identify the up-to-date biological effects and underlying mechanisms of astaxanthin on the ROS-induced diabetes mellitus-associated metabolic disorders and subsequent complications

Custom-made macroporous bioceramic implants based on triply-periodic minimal surfaces for bone defects in load-bearing sites

This study showed, for the first time, that custom-made TPMS-based bioceramic implants could be produced and successfully implanted in load-bearing sites

Concise review: Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications

Here, we provide a comprehensive review of plausible metabolic switches in response to implantation and of the various strategies currently used to leverage MSC metabolism to improve stem cell-based therapeutics.

Effect of the bone morphogenetic protein-2 doses on the osteogenic potential of human multipotent stromal cells-containing tissue engineered constructs

Our results showed that the addition of only low dose of BMP-2 was beneficial to enhance the bone-forming potential of MSCs, whereas high dose of BMP-2 overcame the advantage of combining this growth factor with MSCs.

Feasibility of bioengineered tracheal and bronchial reconstruction using stented aortic matrices

In this uncontrolled study, airway bioengineering using stented aortic matrices demonstrated feasibility for complex tracheal and bronchial reconstruction.

Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats

The present study provided evidence that T2DM impairs bone formation in critical-size calvarial defects and markedly reduces angiogenesis in all defects regardless of the defect size tested.