Laboratory of Osteoarticular Biology, Bioengineering and Bioimaging UMR CNRS 7052 INSERM U1271

The laboratory of Osteoarticular Biology, Bioengineering and Bioimaging  (B3OA) UMR CNRS 7052 INSERM U1271 is affiliated with the CNRS Department of Science for Engineers , with the INSERM , with the Paris Cité University   and with the Ecole Nationale Vétérinaire de Maisons-Alfort .

Since its creation in 1977, the B3OA has developed a renowned expertise for repair and imaging of osteoarticular tissues. Based on its experience, the mission of the B3O lab is to provide world-class research and education on osteo-articular bioengineering and imaging.

The B3OA lab's important knowledge and unique expertise in tissue engineering, medical imaging and cellular and molecular biology enables it to develop innovative, multidisciplinary approaches for orthopedics, dentistry and radiology.

Our latest news

New lab member: Ayma JEBARI

Ayma JEBARI is a master student who joined the B3OA lab in April 2023.

New lab member: Margaux SOLOY

Margaux SOLOY is a M2 student in STAPS at the University of Orléans. She joined the B3OA lab in March 2023.

New lab member: Eya SAIDI

Eay SAIDI is a student in M2 at the Higher Institute of Applied Biological Sciences of Tunis. She joined our laboratory on March 2023.

3R Track Award

A young surgeon from Ile-de-France is rewarded for her research on bone regeneration.

New lab member: Sacha KUZNIAK

Sacha KUZNIAK is a student in M1 at the University of Technology of Compiègne. He joined our laboratory on February 2023.

Surgeons of the Future: Sarah SCHOFFIT, winner of the 3R award

Sarah SCHOFFIT, M2 student at the B3OA laboratory, is the recupient of a Surgeons of the Future award.

New lab member: William BAKARI

William BAKARI is a Master M2 student from the Paris Cité University and Sorbonne Paris Nord University, who joined the B3OA in January 2023.

Our latest publications

A New Microarchitecture-Based Parameter to Predict the Micromechanical Properties of Bone Allografts

This study presents a novel microarchitectural parameter that could be used to predict the level of mechanical stimulation at the cellular level, a key parameter to better understand and optimize the mechanism of osteogenesis in bone tissue engineering.

Three-dimensional Printing of Biomimetic Titanium Mimicking Trabecular Bone Induces Human Mesenchymal Stem Cell Proliferation: An In-vitro Analysis

The aim of this study was to assess the effect of three-dimensional (3D) printing of porous titanium on human mesenchymal stem cell (hMSC) adhesion, proliferation, and osteogenic differentiation.

Glucose Metabolism: Optimizing Regenerative Functionalities of Mesenchymal Stromal Cells Postimplantation

Following a brief overview of glucose metabolism and regulation in MSCs, the present literature review includes recent pertinent findings that challenge old paradigms and notions

Mitohormesis and mitochondrial dynamics in the regulation of stem cell fate

This review aimed to provide an update to a broader concept of stem cell fate in stress conditions of damaged tissues, and insights for the mitochondrial hormesis (mitohormesis), including the integrated stress response (ISR), mitochondrial dynamics, mitochondria uncoupling, unfolded protein response, and mitokines, with implications for the control of stem cells programing in a successful clinical cell therapy

In Vivo bone tissue induction by freeze-dried collagen-nanohydroxyapatite matrix loaded with BMP2/NS1 mRNAs lipopolyplexes

Overall, our results demonstrate that the BMP2/NS1 dual mRNAs system is suitable for osteogenic engagement, and the freeze-dried RAM-BMP2/NS1 could be promising off-the-shelf products for clinical orthopedic practice