Laboratory of Osteoarticular Biology, Bioengineering and Bioimaging UMR CNRS 7052 INSERM U1271

The laboratory of Osteoarticular Biology, Bioengineering and Bioimaging  (B3OA) UMR CNRS 7052 INSERM U1271 is affiliated with the CNRS Department of Science for Engineers , with the INSERM , with the Paris University   and with the Ecole Nationale Vétérinaire de Maisons-Alfort .

Since its creation in 1977, the B3OA has developed a renowned expertise for repair and imaging of osteoarticular tissues. Based on its experience, the mission of the B3O lab is to provide world-class research and education on osteo-articular bioengineering and imaging.

The B3OA lab's important knowledge and unique expertise in tissue engineering, medical imaging and cellular and molecular biology enables it to develop innovative, multidisciplinary approaches for orthopedics, dentistry and radiology.

Our latest news

New lab member: Louis LEBRETON

Louis LEBRETON is a M1 student from Orléans University]. His master project is entitled: "microarchitectural analysis: effects of physical exercise on bone tissue, comparison between mixed, intermittent and continuous exercise".

New lab member: Caroline CARON

Caroline CARON is a M1 student from Orléans University. Her master project will compare the effects of different training modalities on the quality and repair of tibial bone tissue.

New lab member: Katia KESSIR

Katia KESSIR is a M2 student from Orléans University. During her master's project, she will compare calcified cartilage and subchondral plaques between samples of healthy human knees and those of…

New lab member: Sara KRIM

Sara KRIM is a M2 student from Orléans University. Her master project will focus on the immunohistochemical study of the effects of different exercise modalities on bone tissue and its…

Seeking Horizon 2021 Marie program Skłodowska-Curie Individual Fellowship candidates

The B3OA laboratory seeks to develop funding proposals in collaboration with experienced researchers for submission to the Horizon 2021 Marie program Skłodowska-Curie Individual Fellowship (IF) in the field of skeletal…

Seeking China Scholarship Council post-doctoral program candidates

The B3OA laboratory seeks highly motivated post-doctoral candidates to develop funding proposals for submission to the China Scholarship Council post-doctoral program in the field of skeletal and intervertebral disc tissue…

Seeking PhD candidate

A thesis, funded by an ANR contract, is proposed in theme 2 of the B3OA, "Translational aspects of bone repair". The ultimate goal of the project is to repair large…

Our latest publications

Experimental Type 2 Diabetes Differently Impacts on the Select Functions of Bone Marrow-Derived Multipotent Stromal Cells

These results provided evidence that the type 2 diabetes environment impairs multipotent stromal cell expansion and select functions pertinent to their efficacy when used in autologous cell therapies.

Human dentin characteristics of patients with osteogenesis imperfecta: insights into collagen-based biomaterials

We investigated the collagen, mineral and mechanical properties of dentin from deciduous teeth collected from patients with mild form of osteogenesis imperfecta and displaying no obvious clinical signs of dentinogenesis imperfecta. For the first time, an increase in the hardness of osteogenesis imperfecta dentin associated with an increase in mineral content compared to healthy patients was reported.

Does physical exercise always improve bone quality in rats?

This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality.

Does eccentric-concentric resistance training improve early functional outcomes compared to concentric resistance training after total knee arthroplasty?

This study showed that early combined eccentric-concentric rehabilitation after total knee arthroplasty appears to be associated with improved outcomes compared to classic concentric rehabilitation protocols, on both physical function and quality of life.

Osteogenic-differentiated mesenchymal stem cell-secreted extracellular matrix as a bone morphogenetic protein-2 delivery system for ectopic bone formation

This study provided evidence that the osteoinductive potential of BMP-2 was greater when loaded within an osteogenic MSC-derived ECM.