Laboratory of Osteoarticular Biology, Bioengineering and Bioimaging UMR CNRS 7052 INSERM U1271
The laboratory of Osteoarticular Biology, Bioengineering and Bioimaging (B3OA) UMR CNRS 7052 INSERM U1271 is affiliated with the CNRS Department of Science for Engineers , with the INSERM , with the Paris University and with the Ecole Nationale Vétérinaire de Maisons-Alfort .
Since its creation in 1977, the B3OA has developed a renowned expertise for repair and imaging of osteoarticular tissues. Based on its experience, the mission of the B3O lab is to provide world-class research and education on osteo-articular bioengineering and imaging.
The B3OA lab's important knowledge and unique expertise in tissue engineering, medical imaging and cellular and molecular biology enables it to develop innovative, multidisciplinary approaches for orthopedics, dentistry and radiology.
Our latest news
Rebecca is a PhD candidate. She will work on the impact of oxidative stress induced by the diabetic microenvironment on bone repair and on the therapeutic potential of mesenchymal stem…
Pauline is a PhD candidate. She will work on the development of a composite biomaterial able to increase the survival and functionality of Mesenchymal Stem Cells transplanted into a large…
Contribution to the understanding and prevention of cell death of mesenchymal stem cells after implantation: Application to tissue engineering
PhD defended by Cyprien DENOEUD on 30-09-2019
The documentary recounts the 5 original encounters between Villejuif residents, which took place in spring 2019 at the Elsa-Triolet Media Library in Villejuif, as part of the 80th CNRS anniversary…
Fractures: the amazing healing ability of our bones!
Our latest publications
Concise review: Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications.
Here, we provide a comprehensive review of plausible metabolic switches in response to implantation and of the various strategies currently used to leverage MSC metabolism to improve stem cell-based therapeutics.
Effect of the bone morphogenetic protein-2 doses on the osteogenic potential of human multipotent stromal cells-containing tissue engineered constructs
Our results showed that the addition of only low dose of BMP-2 was beneficial to enhance the bone-forming potential of MSCs, whereas high dose of BMP-2 overcame the advantage of…
In this uncontrolled study, airway bioengineering using stented aortic matrices demonstrated feasibility for complex tracheal and bronchial reconstruction.
Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats
The present study provided evidence that T2DM impairs bone formation in critical-size calvarial defects and markedly reduces angiogenesis in all defects regardless of the defect size tested.