Principal investigators: F. Anagnostou, H. Petite

Investigators: M. Bensidhoum, S. Pallu, H. Portier, V. Bousson, R. Landon

Diabetes is a major, and still growing, public health problem. This chronic condition is associated with abnormally high levels of sugar (glucose) in the blood, causing serious long-term complications including cardiovascular disease, stroke, kidney failure, foot ulcers and damage to the eyes. Bone tissue is also affected by this health condition. Specifically, diabetes alters formation and homeostasis of the bone tissue and delays its repair.
Despite its important clinical impact, the data on diabetes and bone healing are scarce and even contradictory, and the mechanisms affected by a diabetic environment are still to be identified. Therefore, improving bone repair in a diabetic environment remains a challenge. Because of their role in bone healing, MSCs are regenerative cells of choice, although not yet fully exploited, for this clinical application.
The B3OA aims to develop cellularized biomaterial for bone defect repair in diabetic patient and identify the underlying the molecular and cellular mechanisms.

Publications of the project

Caliaperoumal G, Souyet M, Bensidhoum M, Petite H, Anagnostou F. Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats. Bone. 2018 ;112:161-172.5.  Link for the publication .

Ribot J, Caliaperoumal G, Paquet J, Boisson-Vidal C, Petite H, Anagnostou F. Type 2 diabetes alters mesenchymal stem cell secretome composition and angiogenic properties. J Cell Mol Med. 2017;21(2):349-363. Link for the publication .