Photo C Bourzac

Defended by Céline BOURZAC on 16-12-2020

Thesis director: Hugues PORTIER, Morad BENSIDHOUM


It is now well established that physical exercise has unquestionable beneficial effects on bone tissue and metabolism. However, no consensus regarding the osteogenic effects of exercise on healthy or healing bone has been reached yet. The objective of this work is (i) to evaluate the effects of two running protocols (continuous vs. intermittent) on the parameters of bone quality and bone metabolism, and (ii) to evaluate the preventive effects of these running protocols on bone repair in Wistar rats.
We demonstrated here that high-intensity interval-running has positive effects on cortical bone quality, while moderate continuous running has beneficial effects on trabecular bone but is detrimental to cortical bone. These effects also depend on the bone (tibia vs. femur). In addition, our data suggest that both running protocols accelerate the repair of a non-critical bone defect in the tibia but not in the femur, possibly by modulating bone resorption.
Associating different types of running is more beneficial to bone health than just one. As part of the refinement of animal models, the use of the tibia would be more suitable to study bone healing than the femur.

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