Defended by Rebecca LANDON on December 19, 2023
![](https://www.b3oa.cnrs.fr/wp-content/uploads/2024/01/Rebecca03.jpg)
Defended by Rebecca LANDON on December 19, 2023
We hereby propose a paradigm shift for enhancing MSC survival by designing, developing, and testing an enzyme-controlled, nutritive hydrogel with an inbuilt glucose delivery system.
Our publication on the development of a nutritive hydrogel is highlighted by the CNRS Ingénierie.
The present study provided evidence for glucose depletion as an essential player in NP cell viability but also suggested that other microenvironment factor(s) may be involved in triggering the typical shift of NP cell phenotype observed during disc degeneration.
PhD defended by Angelina AVGERI on December 14, 2023 PhD advisors: Pascal BIZOT, Elisa BUDYN Visit the theses.fr website
These results show that the physico-chemical properties of collagen/THA composite hydrogels and GDF5/TGFβ1 act in synergy to promote the differentiation of BM-MSCs into NP like cells.
A new osteoinductive medical device is developed here for long bone repair by combining a 3D-printed architectured cylindrical scaffold made of clinical-grade polylactic acid (PLA) with a polyelectrolyte film coating delivering the osteogenic bone morphogenetic protein 2 (BMP-2).
These results proved that ATSCs are a transient source of inflammatory cytokines promoting a transient immune response post-implantation; this milieu correlates with impaired osteogenic differentiation of both the implanted ATSCs and the host osteoprogenitor cells.
Ying TAN will conduct her PhD on multiscale modeling of non-linear mechanical behavior at the B3OA.
Ronan FEAT joined our laboratory in August 2023 for his engineering assistant internship.
Scientists unveil their research and let you discover their everyday laboratory objects!
Vincent CONTREMOULINS joined our laboratory in July 2023 as a CNRS design engineer.
The First NetwOArk Autumn School will be held on November 23rd, 2023 in Paris.
The B3OA is pleased to welcome Yushan SU for her international summer internship.
Benoit DEMUYNCK joined our laboratory in June 2023 as a CNRS engineer.
A young surgeon from Ile-de-France is rewarded for her research on bone regeneration.
This study presents a novel microarchitectural parameter that could be used to predict the level of mechanical stimulation at the cellular level, a key parameter to better understand and optimize the mechanism of osteogenesis in bone tissue engineering.
Ayma JEBARI is a master student who joined the B3OA lab in April 2023.
Margaux SOLOY is a M2 student in STAPS at the University of Orléans. She joined the B3OA lab in March 2023.
Eay SAIDI is a student in M2 at the Higher Institute of Applied Biological Sciences of Tunis. She joined our laboratory on March 2023.
Sacha KUZNIAK is a student in M1 at the University of Technology of Compiègne. He joined our laboratory on February 2023.
Sarah SCHOFFIT, M2 student at the B3OA laboratory, is the recupient of a Surgeons of the Future award.
The aim of this study was to assess the effect of three-dimensional (3D) printing of porous titanium on human mesenchymal stem cell (hMSC) adhesion, proliferation, and osteogenic differentiation.
Following a brief overview of glucose metabolism and regulation in MSCs, the present literature review includes recent pertinent findings that challenge old paradigms and notions
William BAKARI is a Master M2 student from the Paris Cité University and Sorbonne Paris Nord University, who joined the B3OA in January 2023.
Thesis defended by Rokia WAZZANI on December 8, 2022
Rita BAHOUJ is a master student from Cergy-Pontoise University and she joined our lab on January 2023.
Haodong XU is a new PhD candidate at the B3OA Lab working in the “Counteracting intervertebral disc degeneration with new therapeutic strategies” research team.
Brazilian frogs are fluorescent! And this is not their only power…
This review aimed to provide an update to a broader concept of stem cell fate in stress conditions of damaged tissues, and insights for the mitochondrial hormesis (mitohormesis), including the integrated stress response (ISR), mitochondrial dynamics, mitochondria uncoupling, unfolded protein response, and mitokines, with implications for the control of stem cells programing in a successful clinical cell therapy
PhD thesis defended by Mathilde PADRONA on 28.09.2022
Andy XAVIER is a new PhD candidate at the B3OA Lab. His research project will focus on the effects of different running modalities on bone tissue and is part of the “Effect of the physical exercise on bone formation” research… Read More
Overall, our results demonstrate that the BMP2/NS1 dual mRNAs system is suitable for osteogenic engagement, and the freeze-dried RAM-BMP2/NS1 could be promising off-the-shelf products for clinical orthopedic practice
Virtual monoenergetic images may provide direct visualisation of both cartilage and bone details. Thus, unenhanced PCSCT appears to be a new modality for characterising the knee joint with the potential to increase the diagnostic capability of computed tomography for joint diseases and osteoarthritis.
Xavier VESTRIS is a Master M2 student from the Orléans University, who joined the B3OA in February 2022.
Léa ROUQUIER is a PhD candidate at the B3OA since January 2022, in the research theme “Biomedical innovations in orthopaedics: a biophysical approach”
Hasan GHANEM is a Master M2 student from the University of Sorbonne Paris Nord who joined the B3OA in January 2022.
Emeline RASCUSSERY is a M1 student from the University of Cergy-Pontoise who joined the B3OA in January 2022.
Axelle GUEDON is a M2 master student from Université Paris Est Créteil who joined the B3OA in January 2022.
Eva VEISS is a CNRS development engineer. She joined our laboratory on 03/01/2022.
Samantha MAGNIN is a PhD student at the B3OA since November 2021, in the research project “Enhancing MSC survival and functions in an ischemic environment”.
Gabi XIONG is a PhD student at B3OA since October 2021, in the “Biomedical innovations in orthopaedics: a biophysical approach” research theme.
Kim GEELINK is a student engineer from Eindhoven University of Technology, The Netherlands, who joined B3OA in October 2021.
Les Echos talks about the first Unusual 2021 visit of the CNRS, which took place in our laboratory on October 1, 2021.
Margaux WEISS is a student engineer from université de technologie de Compiègne, who joined B3OA on August 2021.
PhD defended by Guotian LUO on 24-09-2021
Guoyan XIAN is a PhD candidate at the B3OA since March 2021, in the research theme “Enhancing MSC survival and functions in an ischemic environment”
Léa ROUQUIER is a student engineer/M2 from Ecole Centrale de Lyon and Claude Bernard Lyon 1 University, who joined B3OA on March 2021.
Samantha MAGNIN is a student engineer from the Ecole Nationale Supérieure des Mines de St-Etienne, who joined B3OA in April 2021.
Amandine LEROUX is a engineer student from Icam. She works on Dragonfly ORS, an image analysis software with Deep Learning components. The objectiveof her project is to improve the processing of explant images acquired by micro-scanner.
Hasan GHANEM is a M1-Health student from Paris University. His master project is entitled: “Evaluation of the regenerative potential of craniofacial bone defects using new biomimetic biomaterials with gyroid macrostructure”.
Louis LEBRETON is a M1 student from Orléans University]. His master project is entitled: “microarchitectural analysis: effects of physical exercise on bone tissue, comparison between mixed, intermittent and continuous exercise”.
Caroline CARON is a M1 student from Orléans University. Her master project will compare the effects of different training modalities on the quality and repair of tibial bone tissue.
Katia KESSIR is a M2 student from Orléans University. During her master’s project, she will compare calcified cartilage and subchondral plaques between samples of healthy human knees and those of an arthritic knee.
Sara KRIM is a M2 student from Orléans University. Her master project will focus on the immunohistochemical study of the effects of different exercise modalities on bone tissue and its vascularization.
The B3OA laboratory seeks to develop funding proposals in collaboration with experienced researchers for submission to the Horizon 2021 Marie program Skłodowska-Curie Individual Fellowship (IF) in the field of skeletal tissue engineering. For more informations, please see “job opportunities” page.… Read More
The B3OA laboratory seeks highly motivated post-doctoral candidates to develop funding proposals for submission to the China Scholarship Council post-doctoral program in the field of skeletal and intervertebral disc tissue engineering, osteo-articular imaging, or physical exercise impact on bone status… Read More
PhD defended by Stéphanie UK on 29-01-2021
These results provided evidence that the type 2 diabetes environment impairs multipotent stromal cell expansion and select functions pertinent to their efficacy when used in autologous cell therapies.
Marie MICOLON is a M1 student from UTC. Her master project will evaluate in vitro the ability of nutritive hydrogels to improve survival, cell phenotype and matrix production of mesenchymal stem cells in a degenerative disc environment.
Lilou BABINET is a M1 student from UTC. Her master project will analyse the osteogenic potential of a new bone substitute in a bone reconstruction model.
PhD defended by Céline BOURZAC on 16-12-2020
Defended by Ahmad Moustapha DIALLO on 13-10-2020
We investigated the collagen, mineral and mechanical properties of dentin from deciduous teeth collected from patients with mild form of osteogenesis imperfecta and displaying no obvious clinical signs of dentinogenesis imperfecta. For the first time, an increase in the hardness of osteogenesis imperfecta dentin associated with an increase in mineral content compared to healthy patients was reported.
This literature review presents for the first time the effects on five exercise models (treadmill running, wheel running, swimming, resistance training and vibration modes) in three different experimental rat groups (males, females, osteopenic) on bone quality.
This study showed that early combined eccentric-concentric rehabilitation after total knee arthroplasty appears to be associated with improved outcomes compared to classic concentric rehabilitation protocols, on both physical function and quality of life.
Our patent “Non invasive process for the evaluation of the quality of internal dense connective tissues” has been nominated by APINNOV for their Promising Patent trophy.
This study provided evidence that the osteoinductive potential of BMP-2 was greater when loaded within an osteogenic MSC-derived ECM.
In the present review, we aimed to identify the up-to-date biological effects and underlying mechanisms of astaxanthin on the ROS-induced diabetes mellitus-associated metabolic disorders and subsequent complications
The invention relates to a non-invasive process for evaluating the quality of one or more dense connective tissue(s) in a patient.
This study showed, for the first time, that custom-made TPMS-based bioceramic implants could be produced and successfully implanted in load-bearing sites
Here, we provide a comprehensive review of plausible metabolic switches in response to
implantation and of the various strategies currently used to leverage MSC metabolism
to improve stem cell-based therapeutics.
PhD defended by Cyprien DENOEUD on 30-09-2019
The documentary recounts the 5 original encounters between Villejuif residents, which took place in spring 2019 at the Elsa-Triolet Media Library in Villejuif, as part of the 80th CNRS anniversary celebrations. This is the opportunity to explore from an original… Read More
Our results showed that the addition of only low dose of BMP-2 was beneficial to enhance the bone-forming potential of MSCs, whereas high dose of BMP-2 overcame the advantage of combining this growth factor with MSCs.
Fractures: the amazing healing ability of our bones!
Defended by Karim OUDINA on 09-2015
Repairing bones with stem cells The use of stem cells for bone repair becomes possible thanks to a nutritive hydrogel developed by researchers from the Laboratory of Osteoarticular Bioengineering and Bioimaging, in collaboration with members of the Ermecee. This hydrogel… Read More
Cryopreserved and then grafted, the transformation of the aorta into a trachea. For a long time difficult, the trachea and bronchi have only had a reliable transplant protocol for a few years. The operation, conducted by doctors from the Paris… Read More
Dr. Adrien Moya has just started a post-doc at the University of Miami in the lab of Paul Schiller. Here we discuss Dr. Moya’s previous work in the CNRS lab at Diderot University in Paris. His recent publication in Stem Cells … Read More
In this uncontrolled study, airway bioengineering using stented aortic matrices demonstrated feasibility for complex tracheal and bronchial reconstruction.
In certain bone pathologies or fractures, the repair strategy of reference is to graft a piece of bone of the patient in th defect to repair. With stem cells seeded onto coral skeleton, one could improve bone repair. For now,… Read More
The medical imaging techniques currently developed make it possible to obtain more and more powerful images. This film presents the work of 4 laboratories specialized in the observation of the bone. A CNRS Image movie. Report from October 2011. Find… Read More
At the Lariboisière Hospital (Paris), research on biomaterials allowed, after implantation of coral seeded with stem cells in sheeps, a good repair of bone defect. While waiting for the applications on the man … An episode of the series “Des… Read More
What are the bones used for? How do our joints handle shocks? What happens when you have a sprain or dislocation? How is the skeleton formed during fetal life? And during growth, how do the bones lengthen? What is scoliosis?… Read More
Artificial retina, glasses equipped with cameras? Technology to help the visually impaired? Synthetic blood: soon a reality? To meet the needs of the sick and wounded, the researchers managed to make “blood”? Artificial skin created in the laboratory? E =… Read More
The invention relates to a method for controlling the mechanical strength of a part inserted at least partially in a body.
The invention relates to an implant device and a delivery tool.
The invention relates to a method for culturing bone tissue.
The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.
The present study provided evidence that T2DM impairs bone formation in critical-size calvarial defects and markedly reduces angiogenesis in all defects regardless of the defect size tested.
Defended by Adrien MOYA on 14-09-2016
Defended by Jonathan RIBOT on 15-12-2015