G.E. Salazar-Noratto, G. Luo, C. Denoeud, M. Padrona, A. Moya, M. Bensidhoum, R. Bizios, E. Potier, D. Logeart-Avramoglou, H. Petite

STEM CELLS. 2019;1–12

DOI: 10.1002/stem.3079

In tissue engineering and regenerative medicine, stem cell—specifically, mesenchymal
stromal/stem cells (MSCs)—therapies have fallen short of their initial promise and
hype. The observed marginal, to no benefit, success in several applications has been
attributed primarily to poor cell survival and engraftment at transplantation sites.
MSCs have a metabolism that is flexible enough to enable them to fulfill their various
cellular functions and remarkably sensitive to different cellular and environmental
cues. At the transplantation sites, MSCs experience hostile environments devoid or,
at the very least, severely depleted of oxygen and nutrients. The impact of this particular
setting on MSC metabolism ultimately affects their survival and function. In
order to develop the next generation of cell-delivery materials and methods, scientists
must have a better understanding of the metabolic switches MSCs experience
upon transplantation. By designing treatment strategies with cell metabolism in mind,
scientists may improve survival and the overall therapeutic potential of MSCs. Here,
we provide a comprehensive review of plausible metabolic switches in response to
implantation and of the various strategies currently used to leverage MSC metabolism
to improve stem cell-based therapeutics.

Please find here the original publication